Neuroendocrine tumors are rare and develop most commonly in the lungs, appendix, small intestine (duodenum), rectum and pancreas.
Alternate Names : Islet cell tumors, Islet of Langerhans tumor, Neuroendocrine tumors
Definition
A pancreatic islet cell tumor is an uncommon tumor of the pancreas that arises from a type of cell called the islet cell in the pancreas.
Neuroendocrine Tumors of the Pancreas
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Neuroendocrine tumors may associated with the following conditions inherited genetically:
multiple endocrine neoplasia (MEN) types 1 and 2
von Hippel-Lindau (VHL) disease ...
NEUROENDOCRINE TUMORS
A substantial evolution of concepts of neuroendocrine lung tumor classification has occurred. LCNEC is recognized as an histologically high-grade non-small cell carcinoma. It has a very poor prognosis similar to that of SCLC.
Some neuroendocrine tumors in the pancreas include the following - they may be benign (noncancerous) or malignant (cancerous):
Insulinoma - a rare pancreatic tumor that secretes insulin, the hormone that lowers glucose levels in the blood.
Research for neuroendocrine tumors is ongoing. The following advances may still be under investigation in clinical trials and may not be approved or available at this current time. Always discuss all diagnostic and treatment options with your doctor.
Starker LF, Carling T: Molecular genetics of gastroenteropancreatic neuroendocrine tumors. Curr Opin Oncol 21 (1): 29-33, 2009.
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Farnebo F, Teh BT, Kytölä S, et al.: Alterations of the MEN1 gene in sporadic parathyroid tumors.
Seneca Valley virus-001 (SEH-nih-kuh VA-lee VY-rus.) A virus being studied in the treatment of neuroendocrine tumors and other types of cancer.
Carcinoid and other neuroendocrine tumors. In: Travis WD, editor. Tumors of Lower Respiratory Tract. Washington DC: Armed Forces Institute of Pathology; 1995. p. 311.
^ Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y.
Neuroendocrine tumors - more precisely known as gastroenteropancreatic neuroendocrine tumors or gastro-entro-pancreatic tumors - are neoplastic growths that attack the interface between the endocrine (hormonal) system and the nervous system.
MIBG (metaiodobenzylguanidine) scan: A procedure used to find neuroendocrine tumors, such as neuroblastomas and pheochromocytomas. A small amount of radioactive material called MIBG is injected into a vein and travels through the bloodstream.
Chromogranin A is used as a marker for carcinoid and other neuroendocrine tumors. Sensitivity and specificity for neuroendocrine tumors can exceed 75%, and diagnostic accuracy is higher with diffuse than with localized tumors.
Endrocrine tumors are often grouped as neuroendocrine tumors or islet cell tumors. The subtypes of islet cell tumors are named according to the type of hormone-making cell from which they originate.
A now universally approved (though costly) way of finding carcinoid tumors, as well as other neuroendocrine tumors, is the OctreoScan.
Expert-reviewed information summary about the treatment of pancreatic cancer.
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®) ...
Phorbol, Failures, Equipment, Food Chains, Gliostatin, Hexamethylmelamine, Hibernomas, Identification System, Personal, Kinase, Adenosine, Leiomyosarcoma, Mastectomy, Modified Radical, Modane, Nervous System Malformations, Neuroendocrine Tumors, ...
Islet cell tumors, also known as neuroendocrine tumors, are less common and more likely to be benign. Normally, the pancreas' islet cells produce insulin and other hormones. Islet cell tumors can also produce these hormones.
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 2011… more…
Second-line Combination Chemotherapy… ...
Islet cell tumors; Islet of Langerhans tumor; Neuroendocrine tumors
Causes, incidence, and risk factors ...
Some examples of neuroendocrine tumors are carcinoid tumors, islet cell tumors, medullary thyroid carcinoma and pheochromocytoma. These tumors secrete hormones in excess, causing a variety of symptoms.
This term describes all of the following types of tumors: neuroendocrine tumors (carcinoids), adenoid cystic carcinomas (cylindromas), mucoepidermoid carcinomas, mucous gland adenomas, ...
Cholangiocarcinoma
Breast cancer or lung cancer with liver metastasis
Neuroendocrine tumors, such as carcinoid tumors, that have spread to the liver ...
The Caring for Carcinoid Foundation (CFCF) provides a wealth of ... Carcinoid Syndrome - Mayo Clinic. Neuroendocrine Tumors - Dana-Farber Cancer Institute ...
Full article ...
National Comprehensive Cancer Network. Clinical practice guidelines in oncology. Neuroendocrine tumors. v.2.2010.
5-HIAA levels in urine
Blood tests (including serotonin blood test)
CT and MRI scan
OctreoScan (to identify most carcinoids and other neuroendocrine tumors) ...
A series of studies published in the latest issue of the Journal of Nuclear Medicine show that molecular imaging plays a critical role in the evaluation and treatment of a spectrum of cancers, including thyroid cancer, neuroendocrine tumors, ...
The common hormones released are serotonin, bradykinin (a molecule produced by enzymes at the site of an injury and then binds to receptors to cause pain), histamine, and chromogranin A (a general marker for neuroendocrine tumors).
Vascular tumors may also occur in the kidneys (renal cell carcinoma), pancreas (cysts or pancreatic neuroendocrine tumors) and/or adrenal glands (pheochromocytoma).
 See also: Neuroendocrine tumor, Cancer, Symptom, Surgery, Carcinoma
  
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