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Overlap syndrome

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Overlap Syndrome
Term often used to describe a connective tissue disorder with features suggesting more than one type; or Undifferentiated connective tissue disorder.

 


Overlap syndrome
This is diffuse or limited systemic sclerosis with features of one or more of the other connective tissue diseases.

Patients can have overlap syndromes that involve any combination of the connective tissue diseases. Therefore, patients can have a combination, for example, of rheumatoid arthritis and systemic lupus erythematosus (hence, the coined name "rhupus").

Raynaud's phenomenon, scleroderma, and overlap syndromes. BMJ. 1995 Mar 25;310(6982):795-8.
Black, Carol; Scleroderma in 2005: Have we made progress?; Talk presented at Scleroderma Society Annual Conference ...

It is now known that overlap syndromes can occur that involve any combination of the connective tissue diseases.

Detailed testing of the antinuclear antibodies (ANA), when present, is important in identifying other overlap syndromes, most often those with another autoimmune disorder.

Localized Cutaneous Sclerosis as a part of an overlap syndrome
Mixed connective tissue disease
Undifferentiated connective tissue disease
Sclerodermatomyositis ...

Cowden/Bannayan-Riley-Ruvalcaba overlap syndrome
Bannayan-Riley-Ruvalcaba syndrome
PTEN Hamartoma Tumor syndrome
Macrocephaly, pseudopapilledema, multiple hemangiomata syndrome
Macrocephaly, multiple lipomas, hemangiomata syndrome ...

Rodriguez-Reyna TS, Alarcon-Segovia D. Overlap syndromes in the context of shared autoimmunity. Autoimmunity . 2005;38:219-223.

Mycophenolate mofetil for patients with autoimmune hepatitis and overlap syndromes: authors' reply… more…
Choice of Calcineurin Inhibitor May… ...

Calcinosis, CREST, cutaneous systemic sclerosis, diffuse cutaneous systemic sclerosis, hardened skin, limited cutaneous systemic sclerosis, linear scleroderma, localized scleroderma, morphea scleroderma, overlap syndromes, Raynaud's phenomenon, ...

Sometimes it can be difficult to distinguish between a myelodysplastic syndrome and an MPD. You may be classified as having an overlap syndrome.
Essential thrombocythaemia (ET) ...

Systemic lupus erythematosus
Drug-induced lupus
Neonatal lupus
Overlap syndrome
Bullous systemic lupus erythematosus
Lupus erythematosus tumidus
Subcutaneous lupus erythematosus psoariasiform type
More rare types » ...

Myelomastocytic overlap syndromes: biology, criteria, and relationship to mastocytosis, Leuk. Res. 25 (2001) 595- 602.
^ Cather J. C., and Menter M. A., MD, "Red-brown skin lesions and pruritus", BUMC Proceedings 2000;13:179-199.

See also: Symptom, Immune System, Arthritis, Scleroderma, Kidney

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