Polyostotic fibrous dysplasia

Alternate Names : Polyostotic fibrous dysplasia
Definition
McCune-Albright syndrome is a genetic disease that affects the bones and color (pigmentation) of the skin.

Polyostotic fibrous dysplasia - the abnormal growth of two or more bones. Bones of the face, skull, arms and legs are commonly affected ...

Polyostotic fibrous dysplasia
Causes, incidence, and risk factors
McCune-Albright syndrome is caused by mutations in the GNAS1 gene. The abnormal gene is present in a fraction, but not all, of the patient's cells (mosaicism).

Polyostotic fibrous dysplasia
Definition of McCune-Albright syndrome:
McCune-Albright syndrome is a genetic disease that affects the bones and color (pigmentation) of the skin.

Polyostotic fibrous dysplasia can often be seen in a plain X-ray picture of the skeleton.

McCune-Albright's Polyostotic Fibrous Dysplasia
The skin pigmentation, seen in approximately 50% of McCune-Albright patients, is often present in infancy, and is thus...
Neurodegenerative Disorders ...

Those with McCune-Albright syndrome often have polyostotic fibrous dysplasia (pronounced pa-lee-oh-STOT-ik FIE-bruss diss-PLAY-jsha), which occurs when normal bone is replaced by softer, fibrous tissue.

People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia.

Undergrowth may occur with idiopathic hemihypotrophy, Russell Silver syndrome, Turners syndrome with mosaicism, cerebral palsy, poliomyelitis, multiple chondromatosis, multiple enchondromatosis or polyostotic fibrous dysplasia.

In monostotic fibrous dysplasia, the prognosis is excellent if the bone can be strengthened.
In polyostotic fibrous dysplasia, several operative procedures may be necessary to achieve bone strength and to correct the deformity.

AllRefer Health - McCune-Albright Syndrome (Polyostotic Fibrous Dysplasia)
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McCune-Albright syndrome ...

Children and adults with other hereditary abnormalities, including exostoses (bony growths), retinoblastoma, Ollier's disease, osteogenesis imperfecta, polyostotic fibrous dysplasia, and Paget's disease, ...

Most people with the disorder have only one affected bone — a form called monostotic fibrous dysplasia — and develop no signs or symptoms. When the condition affects more than one bone, it's known as polyostotic fibrous dysplasia.

Albright syndrome: A genetic disorder of bones, skin pigmentation and hormonal problems with premature sexual development. Also called McCune-Albright syndrome and polyostotic fibrous dysplasia.

See also: Dysplasia, Fibrous dysplasia, McCune-Albright syndrome, Symptom, Arthritis