Prader-Willi syndrome

Prader-Willi syndrome
Prader-Willi syndrome is a rare genetic disorder, which affects development and growth.

Prader-Willi syndrome
Definition
Prader-Willi syndrome is a congenital (present from birth) disease that involves obesity, decreased muscle tone, decreased mental capacity, and sex glands that produce little or no hormones.

Prader-Willi syndrome
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Prader-Willi Syndrome
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Prader-Willi Syndrome
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Can Prader-Willi syndrome be inherited?
Most cases of Prader-Willi syndrome are not inherited, particularly those caused by a deletion in the paternal chromosome 15 or by maternal uniparental disomy.

Prader-Willi Syndrome
What is Prader-Willi syndrome?
Prader-Willi Syndrome is the most common genetic cause of life-threatening obesity in children.

The fat and red-faced boy in a state of somnolency described by charles dickens in his novel the pickwick papers is thought by some to have had Prader-Willi syndrome. (the same boy inspired the naming of the pickwickian syndrome).

What is Prader-Willi syndrome (PWS)?
Prader-Willi syndrome (PWS), on the other hand, results when a baby inherits both copies of a section of chromosome #15 from the mother. Babies born with PWS have poor muscle tone and a weak cry.

Prader-Willi syndrome is characterized by diminished fetal activity, muscular hypotonia, and failure to thrive during early childhood, obesity from early childhood, intellectual disability, and hypogonadotropic hypogonadism.

Prader-Willi syndrome (PWS) is a genetic disorder characterized by low muscle tone, short stature if not treated with growth hormone, incomplete sexual development, and a chronic feeling of hunger that, ...

Prader-Willi syndrome
Introduction
Prader-Willi syndrome is a rare genetic disorder characterized by decreased muscle tone, mental retardation and an intense desire to eat, which can lead to morbid obesity.

Prader-Willi syndrome is a rare genetic disorder. It is characterized by:
Developmental delays
Insatiable appetite leading to obesity by age six
Mental disabilities
Incomplete sexual development
Short adult stature ...

Prader-Willi syndrome (PWS) is the most common known genetic cause of life-threatening obesity in children. It occurs in males and females equally and in all races.

Prader-Willi syndrome, a disorder in which the genitals are underdeveloped; often testes don't descend
Myotonic dystrophy, or adult muscular dystrophy
Other causes in young men include: ...

Prader-Willi syndrome is a condition characterized by severe floppiness (hypotonia), poor growth, delayed development, and poor feeding problems in early infancy later followed in infancy by excessive eating that may lead to extreme obesity.

Prader-Willi syndrome - A combination of birth defects caused by inheriting both copies of a section on the #15 chromosome from the mother or by inheriting a deletion of a region of chromosome #15 from the father.

Definition Prader-Willi syndrome (PWS) is a genetic condition caused by the absence of chromosomal material from chromosome 15. The genetic basis of PWS is complex.

Trisomy 9p and Prader-Willi syndromes in an infant resulting from a de-novo unbalanced t(9;15)… more…
Characteristic Facial Dysmorphism,…
By de Die-Smulders C, Vles H, Fryns JP ...

Angelman syndrome
Prader-Willi Syndrome
Spinal muscular atrophy
Trisomy 13 syndrome
Hemochromatosis
Dyspraxia treatment
Retinitis pigmentosa treatment ...

Uniparental Disomy: Prader-Willi Syndrome, Angelman Syndrome
Uses of Genetic Testing
Varicella and Pregnancy
Vitamin, Gene, and Enzyme Replacement Therapy ...

Prader-Willi Labhart see Prader-Willi syndrome
Prader-Willi syndrome
Pre-eclampsia
Pre-eclamptic Toxaemia see Pre-eclampsia
Precocious Puberty see Premature Sexual Maturation
Premature Adrenarch see Premature Sexual Maturation ...

Adults with Prader-Willi syndrome: a survey of 232 cases. Dev Med Child Neurol. 1987 Apr;29(2):145-52. Abstract
â†' Cassidy SB, Schwartz S. Gene Reviews: Prader-Willi syndrome.
â†' Feller ER, Ribaudo S, Jackson ND.

Hypotonia may be caused by trauma, environmental factors, or by genetic, muscle, or central nervous system disorders, such as Down syndrome, muscular dystrophy, cerebral palsy, Prader-Willi syndrome, myotonic dystrophy, and Tay-Sachs disease.

Prader-Willi syndrome ... small penis
Priapism ... painful erection
Primary prostate cancer ... Impotence
Prolactinoma ... impotence
Prolactinoma, familial ... erectile dysfunction
Prostate Cancer ... blood in semen, erection difficulty ...

For instance, two different disorders - Prader-Willi syndrome and Angelman syndrome -- are due to deletion of the same part of chromosome 15.

Growth problems may be a feature of syndromes such as Cushing's syndrome, Turner syndrome, Down syndrome, Noonan syndrome, Russell-Silver syndrome and Prader-Willi syndrome.
Growth hormone deficiency.

Your doctor will look for physical or emotional reasons for your child's weight gain, including Prader-Willi syndrome Opens New Window, hypothyroidism Opens New Window, Cushing's syndrome Opens New Window (all of which are rare), ...

Very rare genetic disorders, including Froehlich syndrome in boys, Laurence-Moon-Biedl syndrome, and Prader-Willi syndrome, cause obesity.
Abnormalities or injury to the hypothalamus gland can cause obesity.

Incontinentia pigmenti syndrome
Noonan syndrome
Prader-Willi syndrome
Retinopathy of prematurity
Retinoblastoma
Traumatic brain injury
Trisomy 18 (a child has 3 copies of chromosome 18, instead of the normal 2 copies) ...

Conditions including cystic fibrosis, Cushing's disease, polycystic ovary, or Prader-Willi syndrome
Psychological stress (can lead to a hormonal imbalance sufficient to cause amenorrhea) ...

Turner syndrome (girls)
Klinefelter syndrome (boys)
Prader-Willi syndrome (boys and girls)
Noonan syndrome (boys and girls) ...

Growth hormone injections are also used to treat children with Turner syndrome, Prader-Willi syndrome, chronic kidney failure, or idiopathic short stature (ISS).

Congenital abnormalities of the upper genital system
Craniopharyngioma
Cystic fibrosis
Gonadal dysgenesis
Prader-Willi syndrome
Testicular feminization syndrome
True hermaphroditism
Turner syndrome (XO) ...

Insulin resistance
Kidney disease (benign renal glycosuria)
Pancreatic disease (pancreatitis, cystic fibrosis)
Prader-Willi syndrome
Salicylate poisoning
Type l glycogen storage disease
Type ll diabetes mellitus ...

Foetal Alcohol syndrome
Global Developmental delay
Speech & Language delay
Prader-Willi syndrome
Dyslexia ...

» Prader-Willi Syndrome Association
» Office of Rare Diseases
» North American Menopause Society
» Nevus Outreach
» National Sleep Foundation ...

Congenital abnormalities of the genital system
Gonadal dysgenesis
Turner's syndrome (XO)
Testicular feminization syndrome
True hermaphroditism
Cystic fibrosis
Craniopharyngioma
Prader-Willi syndrome ...

damage to the hypothalamus, a part of the brain where certain functions such as sleep cycles and body temperature are regulated. Froehlich syndrome appears to be acquired while certain other disorders that resemble it, such as Prader-Willi syndrome, ...

Loss of weight due to pain when chewing, swallowing
Numbness over face or mouth area
Enlarged lymph nodes
Down syndrome--prone to gum disease
Prader-Willi syndrome--problems with tooth enamel
Inability to concentrate due to discomfort ...

Myotonic dystrophy (a type of muscular dystrophy)
Phelan-McDermid syndrome (Deletion 22q13 syndrome)
Prader-Willi syndrome
Rickets
Sepsis
Spinal muscular atrophy type 1 (Werdnig- Hoffman)
Tay-Sachs disease
Trisomy 13
Vaccine reaction ...

Prader-Willi syndrome
Pregnancy and chickenpox
Premature ejaculation
Premenstrual syndrome
Prepatellar bursitis (housemaid's knee)
Pressure sores
Preventing a stroke
Priapism
Primary biliary cirrhosis
Professional help for strokes ...

or chromosome regions are expressed or not expressed depending on which parent transmitted the chromosome. Abnormalities in the paternally inherited 15q11-13 region (from the father) cause a different genetic condition called Prader-Willi ...

See also: Symptom, Diabetes, Pregnancy, Cancer, Prevention