"Previous work in our lab showed that when these kinase enzymes - Cdk4 or Cdk6 - inappropriately match up with regulatory proteins called cyclin D1 or D2, you get the uncontrolled proliferation of cells that is a hallmark of myeloma relapse," explains senior researcher Dr.
Proliferation - The growth and reproduction of similar cells.
Protein losing enteropathy - The loss of protein in the intestine.
Radiotherapy - The treatment of disease by radiation.
Cell proliferation: An increase in the number of cells as a result of cell growth and cell division.
Cellular adhesion: The close adherence (bonding) to adjoining cell surfaces.
Central nervous system: The brain and spinal cord. Also called CNS.
An increase in the number of cells as a result of cell growth and cell division.
The use of chemical substances to treat disease cytotoxic drugs, often used in combinations, e.g. FEC are used to treat cancer and to kill cancer cells.
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Lymphoid hyperplasia ...
~ of organisms within the phagolysosome eventually ruptures the host cell. The infected pulmonary macrophages are also transported systemically, with the reticuloendothelial system (liver, spleen, bone marrow [most commonly]) being the most heavily infected.
A ~ of vascular channels filled with red blood cells, shown here beneath skin at the left, is consistent with a hemangioma. If large, such a neoplasm can increase cardiac output, leading to heart failure and hydrops fetalis.
The ~ of Wi-Fi and high-speed Internet makes it relatively easy for a hospital to offer such videoconferencing to child patients, Hilfer said.
"I hope it catches on," he said.
T-cell proliferation assays to mitogens, antigens, or irradiated allogeneic WBCs
Low percentage of T cells, lymphopenia, suspected SCID or complete DiGeorge syndrome
Low or absent uptake of radioactive thymidine during cell division indicates a T-cell or combined defect.
When cell proliferation occurs in a controlled and contained manner, the resulting spot is noncancerous (benign) and is commonly referred to as a mole or nevus.
Sometimes, however, pigment cells grow out of control and become a cancerous and life-threatening melanoma.
An excessive proliferation of blood vessels that leads to a mass, most frequently noticed on the skin present since birth
Vomiting of blood ...
The adenomatous proliferation is characterized by different degrees of cell dysplasia (atypia or loss of normal differentiation of epithelium) irregular cells with hyperchromatic nuclei, (pseudo)stratified nuclei, nucleolus, decreased mucosecretion, and mitosis.
~ The reproduction or multiplication of similar forms, especially of cells and morbid cysts.
Prostate-Gland A gland in men that surrounds the neck of the bladder and urethra. The prostate contributes to the production of seminal fluid.
benign vascular proliferation in dogs; resembles cavernous hemangioma.
are uncommonly found in animals except on the scrotum of old bulls, in the dorsal wall of the vagina in mares and on the prepuce in stallions. May also be associated with arteriovenous fistulae.
~ rapid cell division. Promoter DNA sequence to which RNA polymerase binds to initiate transcription. Pro-oxidant an atom or molecule that promotes oxidation of another atom or molecule by accepting electrons.
Significant hyperproliferation of keratinocytes leads to a very thick area of hyperkeratosis. Weight compresses this hyperkeratotic area driving out air, causing the development of a transparent clavus ("corn"). The corn in turn continues this injury and further hyperkeratosis is the result.
Decreases T cell proliferation and inhibits the production of the cytokines tumor necrosis factor (TNF) alpha, interferon-γ, and interleukin-2.
Slideshow: 21 Arthritis Facts: It's A Game Changer
: Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations. Blood 72 (5): 1674-81, 1988.
Liang R, Todd D, Chan TK, et al.: Treatment outcome and prognostic factors for primary nasal lymphoma. J Clin Oncol 13 (3): 666-70, 1995.
epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IGA, Secretory) that serves to protect these ports of entry into the body Immunoblastic Lymphadenopathy A disease characterized by fever, itching, rash, sweating spells, weight loss, proliferation of ...
Analysis of anti-proliferation of curcumin on human breast cancer cells and its mechanism. 83(20):1764-8.
Sansom, C. (2001). Curry component may be chemopreventive for colon cancer. Lancet Oncol, 2(2);67.
Sun, H. (2008).
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development. 2004 May;131(9):2173-81. Epub 2004 Apr 08. PubMed citation
Conti L, Cattaneo E.
Ductal carcinoma in situ (DCIS): A precancerous condition characterized by the clonal proliferation of malignant-looking cells in the lining of a breast duct without evidence of spread outside the duct to other tissues in the breast or outside the breast.
Gall A localized proliferation of plant or parasite tissue that produces an abnormal growth or swelling, usually caused by pathogenic organisms, nematodes, or insects. Honeydew A sticky exudate (containing conidial) produced during one stage of the life cycle of Claviceps purpurea.
Endometrial hyperplasia is a proliferation (excessive growth) or thickening of the endometrium which may involve part or all of the endometrium.
Hyperplasia usually develops in the presence of continuous oestrogen stimulation unopposed by progesterone.
There is no significant necrosis (cell death) or vascular proliferation (increased blood vessel growth - cancerous tumours create extra blood vessels).
Grade II - slow-growing tumours with more rapidly dividing cells. There is no significant necrosis or vascular proliferation.
The rapid proliferation of abnormal myeloid WBCs and their reduced ability to mature and to die normally results in their accumulation in the bone marrow. This can lead to bone marrow failure and the shutting down the marrow's production of normal WBCs, RBCs, and platelets.
A grade II tumor does not have mitosis, vascular proliferation (blood vessels growing to the tumor), or necrosis (dead cells in the tumor), but shows increased cellularity (an abnormally large number of cells).
Of course, retarding the growth and proliferation of cold sores is not the only trick up lysine's sleeve.
In normal development, neuron proliferation - the process in which nerve cells divide to form new generations of cells - is regulated so that the correct number of cells is produced in the proper place at the appropriate time.
A hematopoietic growth factor which promotes proliferation and maturation of neutrophil granulocytes.
coli (EIEC) is distinguished by the presence of a plasmid containing genes that code for Shiga-like toxin which permits invasion, proliferation and ultimately destruction of epithelial cells. EIEC is contracted by ingestion of contaminated food or water.
What is a beryllium lymphocyte ~ test (BeLPT)?
The beryllium lymphocyte ~ test (BeLPT) is a test that measures beryllium sensitization, which is the immune system's reaction to beryllium.
These are biological substances that exert their influence by causing cellular growth and ~. In an ideal wound-healing situation, new tissue growth would replace damaged tissue resulting from a wound with no functional or cosmetic impairment.
Gestational Trophoblastic Disease ( GTD) is a group of disorders that result in the abnormal ~ of placental (trophoblastic) tissue. Molar pregnancy, which accounts for 80% of GTD, is a rare condition that occurs in about one in every 2,000 pregnancies in the U.S.
apoptosis ; cancer ; cell ; cell division ; cell ~ ; chromosome ; dysplasia ; gastrointestinal ; gene ; genitalia ; hepatosplenomegaly ; hernia ; hypertelorism ; incidence ; intestine ; kidney ; macrocephaly ; macroglossia ; macrostomia ; mental retardation ; mutation ; nerve cell ; ...
Skin biopsy shows vascular ~ and infiltration of vessel walls by neutrophils and clumps of organisms seen with Warthin-Starry silver staining.
2. infectious disease characterized by fever and granulomatous cutaneous lesions. There are two forms.
Mutations in genes that control normal cell ~ can lead to cancer. These mutations can be created by DNA-damaging carcinogens such as cigarette by-products and radiation.
Leukemia is a neoplastic diseases of the bone marrow in which unrestrained ~ of white blood cells occurs, usually accompanied by anemia, impaired blood clotting, and enlargement of the lymph nodes, liver, and spleen.
- Cancer mortality rates higher in men than women ...
In this era of pink ribbons and yellow Livestrong bracelets and a ~ of races to cure cancer, it's easy to forget that just three or four decades ago, a cancer diagnosis was likely a death sentence.
A precancerous condition characterized by the clonal ~ of malignant-looking cells in the lining of a breast duct without evidence of spread outside the duct to other tissues in the breast or outside the breast. DCIS is clearly the precursor (forerunner) of invasive breast cancer.
To identify certain forms of cell ~ as neoplastic, it is necessary to demonstrate that the cell population is genetically identical to a single progenitor cell (clonality). Clonality can be determined if cells grown in vitro propagate indefinitely.
When a woman is pregnant, the hormones estrogen, progesterone and prolactin cause ~ of the lobules and ducts within the breast. While estrogen leads to ~ of the ducts, progesterone helps in the development of the alveoli, lobule and ductal branching and ductal enlargement.
Without essential amino acids, angiogenesis, fibroblast ~, collagen synthesis, and scar remodeling will not occur. Amino acids also support the immune response. Adequate amounts of carbohydrates and fats are needed to prevent the amino acids from being oxidized for caloric needs.
Such damage inhibits skin cell ~ and reduces psoriasis plaque formation. PUVA employs a combination of a psoralen drug and UVA radiation. Forms of psoralen include methoxsalen, 8-methoxypsoralen (8-MOP), or bergapten (5-MOP).
The naevus cells form a row along the dermoepidermal junction (called lentiginous ~), with or without naevus cells in nests (called theques).
These theques are often irregular in size and shape and may 'bridge' or join together.
The cells may be odd-looking i.e.
Eosinophilic esophagitis is inflammation of the esophagus due to an over-~ of white blood cells (eosinophils) in the lining of the esophageal wall. This leads to dysmotility of the esophagus and difficulty swallowing.
Most moles are simply the result of a harmless ~ of the pigment cells within the deeper layer of the skin. A few of these moles, called congenital melanonaevi, are usually present at birth.
A condition characterised by ~ of cells resembling lymphocytes or plasma cells in the bone marrow, anaemia, increased sedimentation rate and hyperglobulinaemia. Physical findings include mucosal bleeding, skin purpura and enlargement of the lymph nodes, liver and spleen.
Mutation Identified That Causes Skin Hyper~
Scientists have identified a mutation in a gene that causes patches of very thick skin to appear on the palms and soles of affected people. This skin disorder is related, albeit in a much milder form, to that of the... [read article] ...
The enlargement of an organ or tissue by the ~ of cells of an abnormal type.
If a mole satisfies at least three of the following criteria, it is defined as dysplastic: larger than 3mm in diameter, poorly defined border, variegated colour, uneven contour and redness ...
Acute glomerulonephritis refers to a specific set of renal diseases in which an immunologic mechanism triggers inflammation and ~ of glomerular tissue. Hippocrates originally described the manifestation of back pain and hematuria, which lead to oliguria or anuria.
A progressive, malignant disease of the blood-forming organs, characterized by distorted ~ and development of leukocytes and their precursors in the blood and bone marrow.
Untreated and/or advanced leukemia results in a ~ of abnormal white blood cells that spread throughout the blood stream. These abnormal cells crowd out normal white blood cells.
Unlike rheumatoid arthritis, the arthritis of SLE tends to be transitory. ~ of the synovium is more limited, and joint destruction is rare. The joints most commonly involved are those of the fingers, wrists, and knees; less commonly involved are the elbows, ankles, and shoulders.
neoplasm - any abnormal growth of new tissue; a ~ of cells no longer under normal physiologic control. These may be benign (non-cancerous) or malignant (cancerous).
neuropathology - the pathology of the nervous system.
Definition Sturge-Weber angiomatosis is developmental condition characterized by ~ of vascular tissues involving the face and the brain. The condition is non-hereditary in nature and is rarely encountered. It is a congenital condition meaning...
Family Health ...
In polycythemia vera, uncontrolled and rapid cellular reproduction and maturation cause ~ or hyperplasia of all bone marrow cells (panmyelosis). The cause of such uncontrolled cellular activity is unknown, but it is probably the result of a multipotential stem cell defect.
The challenge is to learn which mutations are critical to causing cell ~, co-author Maxson explained. "We're working to try to understand which of the mutations drive the cancer and which are just passengers in the car," she said.
Deep gene sequencing ...
A colloid neoplasm of the central nervous system, formed by the ~ of neuroglia cells. [Appleton1904]
A tumor springing from the neuroglia or connective tissue of the brain, spinal cord, or other portions of the nervous system. [Webster1913] ...
hyperplasia: Over~ of normal cells within a normal tissue structure.
hypersomnia: Excessive daytime sleepiness.
hypertension: Persistently high arterial blood pressure.
This thickening is the beginning of intimal ~ and plaque formation. The distribution, severity (amount of plaque), and rate of growth of the plaques in the coronary arteries vary greatly from person to person.
CANCER: a malignant neoplasm or tumor characterized by abnormal cell ~. Types include carcinoma (which affects epithelial cells), sarcoma (which affects soft tissues), lymphoma and leukemia (which affect lymphoid tissue), and glioma (which affects brain tissue).
BeLPT (beryllium lymphocyte ~ test)-a blood test that determines allergic sensitivity to beryllium
Lung biopsy -to test lung tissue using a bronchoscope (a thin, lighted tube that is inserted into the airways) to remove the sample ...
multiple myeloma-A malignant condition characterized by the uncontrolled ~ and dis- ordered function of plasma cells (a type of white blood cell) in the bone marrow. It occurs in middle to old age and leaves patients vulnerable to increased infections and anemia.
That means it involves an overgrowth (~) of lymphatic cells. This makes Castleman disease similar to cancers of the lymphatic system (lymphomas), which also are characterized by cell overgrowth.
MAS results in excessive ~ and activation of specific white blood cell types; T-lymphocytes and macrophages. MAS results in high fever, organ enlargement, anemia, and difficulty with coagulation of the blood. It is described as a secondary form of HLH (see Hemophagocytic Syndrome).
The hormone, oestrogen is responsible for growth and ~ of uterine tissue. Women who have diabetes or endometrial polyps or who are taking hormone replacement therapy are more susceptible for endometrial cancer.
Immunoproliferative Disorders - Disorders characterized by abnormal ~ of primary cells of the immune system or by excessive production of immunoglobulins.
Immunologic Diseases Definitions and Terms ...
Abnormal atypical cellular ~, but not yet advanced enough to be called neoplasia. Usually a forerunner to neoplasia.
Periaqueductal Gray [matter]; Polyacrylamide Gel; Pregnancy-associated Globulin; ~-associated Gene; Proximal Anastomosis Graft; Pulmonary Arteriography
Basle Nomina Anatomica; Bronchoscopic Needle Aspiration ...
Cancer: Caused by problems with cell ~. There are more than 200 different types of cancer.
Phlebitis - A painful swelling of the vein.
PI 3-kinase - An enzyme that plays a crucial role in cell ~ and survival.
Placebo - An inactive substance that looks the same as and is administered in the same way as a drug in a clinical trial.
Histiocytosis: A disease in which histiocytes are the principal cells involved. Langerhans cell histiocytosis is a neoplastic ~ of histiocytes that involves the skin, bone, brain and other organs.
host T: The recipient of a stem cell transplant.
One of the reasons for the rapid ~ of groups focusing on health problems may be the advent of managed health care. For individuals with insurance plans offering limited mental health coverage, self-help groups are an economical way to find emotional and social support.
Several factors can lead to this abnormal ~ of cells, including: ...
The delicate, hazy, tan macular rim of this lesion, although not clinically dramatic, represents persistent melanocytic ~ beyond the lateral limits of the common mole at its center.
Nodular Melanoma ...
glioblastoma multiforme WHO grade IV astrocytoma characterized by hemorrhagic necrosis, endothelial ~, ± crossing of the corpus callosum, ring-enhancement on imaging, and poor survival
gliosis scar or dense fibrous network of glial processes in an area of CNS injury ...
The follicular phase includes the time when menstruation occurs and is followed by ~ or the growth and thickening of the endometrium. This phase typically lasts from 10 to 14 days, starting with the first day of menstruation.
Hyperplasia: An abnormal increase in the number of cells in a specific area, such as the lining of the breast ducts or the lobules. By itself, hyperplasia is not cancerous, but when the ~ (rapid growth) is marked and/or the cells are atypical (unlike normal cells), ...
hnRNP ProteinsA Chain, beta-CrystallinA Dehydrogenase, Isovaleryl-CoenzymeA Disintegrin and Metalloprotease ProteinsA FiberA FibersA gamma GlobinA gamma-GlobinA GeneA GenesA Hydratase, trans-2-Enoyl-CoenzymeA Kinase Anchor ProteinsA Ligases, CoA Ligases, CoenzymeA Polymerase, PolyA ~ ...
Lee, B-S, Margolin, SB, Nowak, RA. "Perdfenidone: A Novel Pharmacological Agent that Inhibits Leiomyoma Cell ~ and Collagen Production." Journal of Clinical Endocrinology and Metabolism. 1998; 83(1); 219-223.
Note: VIN is not a cancer. The word neoplasia is sometimes used when talking of various cancers but its strict definition is an abnormal ~ of cells. With VIN the cells are not cancerous.
Kidneys and spleen swollen.
Microscopically - focal necrosis, bile duct ~ and inflammation.
- Calcium supplements (2000 mg) provide a marked suppression of rectal cancer ~. It inhibits early stages of colon cancer in genetically vulnerable individuals.
A cherry hemangioma is a small non-cancerous, red-purple bump on the skin that is typically seen in older adults. It is formed from a ~ of dilated small veins.
Chickenpox (Varicella) ...
tumor - an abnormal benign or malignant new growth of tissue that possesses no physiologic function and arises from uncontrolled usually rapid cellular ~.
Multiplying or increasing in number. In biology, cell ~ occurs by a process known as cell division.
FOX proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, ~, differentiation, and longevity...
/ winged helix
Winged-helix transcription factors ...
Erythropoietin is a polypeptide hormone present in vertebrates and secreted mainly by the kidneys but also by other organs including the liver. It stimulates the ~ and maturation of erythrocytes in red bone marrow.
Some are deadly, like the Legionella bacterium, while others are relatively benign, especially if treatment can be accessed. One of the biggest problems in the developing world is the ~ of treatable bacterial infections which run unchecked through populations due to lack of access to ...
neoplasm (nE-O-plaz-um) An abnormal tissue that grows by cellular ~ more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
See also: What is the meaning of Cancer, Tumor, Death, Surgery, Infections?