Pulmonary toxicity

Pulmonary Toxicity
Pulmonary toxicity characterized by pulmonary infiltrates and/or fibrosis has been reported to occur from 9 days to 43 months after treatment with BiCNU and related nitrosoureas.

Holland MG. Pulmonary toxicity. In: Shannon MW, Borron SW, Burns MJ, eds. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. 4th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 9.

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The pulmonary toxicity of beryllium. Am Rev Respir Dis 1988; 137: 464-473.
Kreiss K, Newman LA, Mroz M, Campbell PA. Screening blood test identifies subclinical beryllium disease. J Occ Med 1989; 31:603-608.

Patients who are treated with HSCT are at increased risk of pulmonary toxicity, related to pre-existing pulmonary dysfunction (e.g., asthma, pretransplant therapy), the preparative regimen that may include cyclophosphamide, busulfan, carmustine, TBI, ...

During most hyperbaric treatment schedules, pulmonary toxicity is uncommon, although tracheobronchitis due to O2 toxicity can occur during prolonged treatments (e.g., for serious decompression sickness).

"Amiodarone-induced pulmonary toxicity can be progressive and fatal if not recognized and treated."157 See also Death from Amiodarone?

Mitomycin is associated with bone marrow, kidney, mucous membrane, and pulmonary toxicity, as well as kidney failure.

However, respiratory symptoms and changes on chest x-rays in immunocompromised patients may be due to various processes other than infection, such as pulmonary hemorrhage, pulmonary edema, radiation injury, pulmonary toxicity due to cytotoxic drugs, ...

: Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma. J Clin Oncol 23 (30): 7614-20, 2005.
Prosnitz LR, Lawson JP, Friedlaender GE, et al.

See also: Symptom, Cancer, Fever, X-Ray, Death