Toxic multinodular goiter

Alternate Names : Toxic multinodular goiter, Plummer's disease
Definition
Toxic nodular goiter involves an enlarged thyroid gland that contains a small rounded growth or growths called nodules. These nodules produce too much thyroid hormone.

Toxic multinodular goiter; Plummer's disease
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Toxic multinodular goiter: This occurs when part of the thyroid gland produces thyroid hormones all by itself, without regard to TSH stimulation. It usually occurs in people with a long-standing goiter—usually in the elderly.

Nontoxic Multinodular Goiter
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Disorders of Thyroid, Other; Dyshormonogenic Goiter; Congenital Goiter; Goiter Due to Enzyme Defect in Synthesis of Thyroid Hormone; Goitrous Cretinism ...

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Hyperfunctioning thyroid nodule (toxic adenoma, toxic multinodular goiter, Plummer's disease).

It is rare, occurring in patients with Graves' disease or toxic multinodular goiter (a solitary toxic nodule is less common and generally less severe).

Parry's disease: Toxic multinodular goiter. Named for the English physician Caleb Hillier Parry (1755-1822). also called Plummer's disease.
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Diehl LA, Garcia V, Bonnema SJ, et al. Management of the nontoxic multinodular goiter in Latin America: comparison with North America and Europe, an electronic survey. J Clin Endocrinol Metab . 2005;90:117-123.

Another type of hyperthyroidism is toxic nodular goiter (also called toxic multinodular goiter). In this condition, one or more of the thyroid nodules begins to overproduce. These nodules act like benign tumors.

Toxic uninodular goiter-a single area/nodule in the thyroid gland is overactive
Toxic multinodular goiter-multiple nodules in the thyroid gland which overproduce thyroid hormone
Thyroiditis: ...

Symptoms of Hyperthyroidism
Hyperthyroidism can also be caused by a variety of things, including: Graves' disease, toxic multinodular goiter, toxic nodule, excessive intake of iodine, hashitoxicosis, or some medications. The symptoms are: ...

Radioactive iodine is often recommended if you have Graves' disease and are older than 50, or if you have thyroid nodules (toxic multinodular goiter) that are releasing too much thyroid hormone. Radioactive iodine is not used if: ...

If one nodule causes hyperthyroidism, it is called a single toxic nodule.
If several nodules cause the thyroid to become overactive, the condition is called toxic multinodular goiter.

To treat hyperthyroidism associated with toxic multinodular goiter or a toxic adenoma ("hot nodule") (see "Patient information: Thyroid nodules").
To treat women with hyperthyroidism during pregnancy.

See also: Goiter, Symptom, Hyperthyroidism, Hyperthyroid, Thyroid nodule